Neurons themselves do not feel pain, so it is hartis possible that you could take drugs that severely damage your brain without feeling their effects. Note the caveat in the comments: although MDMA is probably neurotoxic, it is still not clear that the neurotoxicity translates to behaviorally meaningful deficits.
Doses of more than mg of MDMA should be considered as high and users should be aware they are at "increased risk of adverse effects", a Wedinos report said. Conversely, headaches and hangovers reflect irritation of the tissue surrounding your brain or of the nerves leading to it. While in some cases a headache can reflect a serious problem that affects or could affect the brain itself e.
If you gave a dose to a human that was sufficient to kill nerve cells, you would kill the human. It is not clear that rare use of MDMA harriz cause lasting cognitive impairment in humans. The real LD50 of nicotine is probably a good bit higher than thought now, but we can't just go poisoning people to really find out so we rely on animal models.
People have died from taking mg of MDMA - ecstasy's active ingredient - though one tablet in Carmarthenshire, submitted for testing, contained mg. The fact that you enjoy taking it doesn't mean that it is not a neurotoxin, just as the fact that I enjoy a martini doesn't mean that alcohol is not carcinogenic.
Most studies are correlational; I have yet to see a longitudinal study that provides convincing evidence that MDMA itself is a causative factor. I am a neuroscientist in training, at least, in a subdiscipline that's only somewhat related but does occasionally involve drugging monkeys.
Tablets submitted in late April in west Wales also showed a separate purple pill, called Givenchy, contained The yellow tablets, moulded into the shape of the Jurassic Park logo, contained three times the level considered a high dose. It has prompted drug analysis project Wedinos to issue a warning to users. I suspect that MDMA and related are somewhat physically harmful but is it more neurotoxic and has a greater addictive potential than legal drugs like alcohol?
I don't think so. Again, not my area of expertise, but I think it's notable that a neuroscientist with a rational attitude toward drugs who recounts his own positive experiences with MDMA says harrsi he wouldn't take it now specifically because of what he claims is conclusive evidence that it kills nerve cells.
There exist studies that have shown such deficits, but there also exist studies that have not. Rats have better tolerance of the effect that mdma has on thermo-regulation and this allows the neurotoxic effect to manifest. Neurons don't necessarily die, but axons disappear. There is good evidence that frequent use and probably even rare use of MDMA is bad for brains.
Like I said, no citation to hand someone else maybe??